Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment.

Cadherin is a homophilic, Ca2+-dependent cell adhesion glycoprotein that mediates cell-cell adhesion. Among them, Cadherin-11 (CDH11), as a classical cadherin, participates in and influences many crucial aspects of human growth and development. Furthermore, The involvement of CDH11 has been identified in an increasing number of diseases, primarily including various tumorous diseases, fibrotic diseases, autoimmune diseases, neurodevelopmental disorders, and more. In various tumorous diseases, CDH11 acts not only as a tumor suppressor but can also promote migration and invasion of certain tumors through various mechanisms. Likewise, in non-tumorous diseases, CDH11 remains a pivotal factor in disease progression. In this context, we summarize the specific functionalities and mechanisms of CDH11 in various diseases, aiming to gain a more comprehensive understanding of the potential value of CDH11 in disease diagnosis and treatment. This endeavor seeks to provide more effective diagnostic and therapeutic strategies for clinical management across diverse diseases.

Association of selenium intake with bone mineral density and osteoporosis: the national health and nutrition examination survey.

Background: Osteoporosis (OP) is a systemic metabolic skeletal disorder characterized by a decrease in bone mineral density (BMD) and an increase in the risk of fracture. The level of selenium (Se) in serum is associated with BMD. However, the relationship between dietary and total selenium intake and parameters such as osteoporosis and BMD is unclear. By conducting National Health and Nutritional Examination Surveys (NHANES), in this study, we assessed the association of Se intake with BMD and the risk of OP among general middle-aged and elderly people. Methods: The data were collected from three cycles of NHANES [2009-2010, 2013-2014, and 2017-2020]. Information on the dietary and supplementary Se intake was obtained from 24-h dietary recall interviews. Additionally, dual-energy X-ray absorptiometry (DXA) was performed to measure BMD, which was later transformed into T-scores; OP was diagnosed when the T-score was ≤ -2.5. We constructed a logistic regression model for the association between selenium intake and the risk of OP based on the estimated odds ratios (ORs) and the 95% confidence intervals (CIs). We also constructed a multivariable linear regression model to analyze the relationship between selenium intake and BMD. Results: In this study, 3,250 individuals (average age: 60.01 ± 10.09 years; 51.88% females) participated. The incidence of OP was 9.35% (3.30% for males and 17.75% for females). In the logistic regression model adjusted for every interested covariate, a higher quartile of dietary Se intake (OR for quartile 4 vs. quartile 1: 0.63; 95% CI: 0.41-0.96; P for trend = 0.027) was related to a lower risk of OP relative to the lowest quartile. The total selenium intake also exhibited a consistent trend (OR for quartile 4 vs. quartile 1: 0.67; 95% CI: 0.44-1.01; P for trend = 0.049). The results of the adjusted multivariate linear regression model showed that the participants with the highest quartile of dietary Se intake (Q4) had higher BMD in the total femur (ß = 0.069, P = 0.001; P for trend = 0.001), femoral neck (ß = 0.064, P = 0.001; P for trend = 0.001), and total spine (ß = 0.030, P = 0.136; P for trend = 0.064) compared to those in quintile 1 (Q1). A similar trend of associations was observed for the total selenium intake with BMD, which was more prominent among females, as determined by the subgroup analysis. Conclusion: In this study, the dietary intake and total intake of selenium were positively associated with BMD, whereas they were negatively associated with the risk of OP among adults in the US. Further studies are required to verify our results and elucidate the associated biological mechanism.

Porphyrin-based Bi-MOFs with Enriched Surface Bi Active Sites for Boosting Photocatalytic CO2 Reduction.

The inherent challenges in using metal-organic frameworks (MOFs) for photocatalytic CO2 reduction are the combination of wide-range light harvesting, efficient charge separation and transfer as well as highly exposed catalytic active sites for CO2 activation and reduction. We present here a promising solution to satisfy these requirements together by modulating the crystal facet and surface atomic structure of a porphyrin-based bismuth-MOF (Bi-PMOF). The series of structural and photo-electronic characterizations together with photocatalytic CO2 reduction experiment collectively establish that the enriched Bi active sites on the (010) surface prefer to promote efficient charge separation and transfer as well as the activation and reduction of CO2 . Specifically, the Bi-PMOFs-120-F with enriched surface Bi active sites exhibits optimal photocatalytic CO2 reduction performance to CO (28.61 µmol h-1 g-1 ) and CH4 (8.81 µmol h-1 g-1 ). This work provides new insights to synthesize highly efficient main group p-block metal Bi-MOF photocatalysts for CO2 reduction through a facet-regulation strategy and sheds light on the surface structure-activity relationships of the MOFs.

Effects of environmental factors on selenite volatilization by freshwater microalgae.

The accumulation and volatilization of Se by algae in surface water are important parts of the biogeochemical cycle of selenium but are also variable and complex. Experiments with 5-8 day of exposure under various temperatures, solution pH values, lighting regimes, and different initial Se concentrations were carried out to study the change in Se accumulation and volatilization behavior of algae. The study showed that algae accumulated and volatilized more Se under harsher environments, such as a lower pH, a shorter lighting time, and a higher Se load. The maximum average daily volatilization rate of Se was 234 ± 23 µg Se (g algae·d)-1, much greater than the values of previous studies. Therefore, in some Se-polluted water environments, when the pH of lakes is acidic, Se emissions to the atmosphere are much higher than currently estimated. Both the accumulation rate (Raccu) and volatilization rate (Rvol) of Se by algae were significantly negatively correlated with final pH, final OD, and residual Se in solution (Cres). Moreover, multiple linear regression equations were used to estimate the rates of Se accumulation and volatilization. This study provides theoretical basis data to quantify the contribution of selenium metabolism by algae to selenium biogeochemistry and a technical reference for the treatment of Se-containing wastewater.

Differences in bioaccumulation of Ni and Zn by microalgae in the presence of fulvic acid.

In the presence of dissolved organic matter, the mechanism of algal bioaccumulation of different metals is complex, and its significance goes far beyond the alga-metal binary system. In the presence of 10 and 20 mg L-1 fulvic acid (FA), the maximum tolerance concentrations of Chlorella pyrenoidosa to Ni were 0.25 and 0.26 mmol L-1, and to Zn were 0.62 and 0.68 mmol L-1, respectively. Within the maximum tolerance concentration ranges, the bioaccumulation behaviors of Ni and Zn were systematically compared in the presence of FA. The presence of FA shortened the adsorption equilibrium time and decreased the maximum bioaccumulation capacity of Ni and Zn. The bioaccumulation mechanism of Ni by C. pyrenoidosa was more inclined to monolayer adsorption, while the bioaccumulation mechanism of Zn was more inclined to multilayer adsorption. More details were revealed after the bioaccumulated metals were separated into adsorption and internalization states by 0.01 M EDTA elution. The presence of FA decreased more adsorbed Zn than the adsorbed Ni, due to the different competitive roles of FA in the ternary system of Ni and Zn, but the presence of FA increased the internalized Ni might due to the stronger complexation of Ni-FA. This research indicated that algae had unique bioaccumulation mechanisms for different metals in the presence of FA, which is of great significance to accurately evaluate the ecological risk posed by heavy metals.

A systematic review and meta-analysis of the correlation between operation time and postoperative delirium in total hip arthroplasty.

BACKGROUND: Delirium is a common postoperative complication of total hip arthroplasty (THA), excessively long time surgery may be one of the factors associated with it. This article aimed to employ literature retrieval and meta-analysis to investigate the correlation between operation time and postoperative delirium in THA. METHODS: The databases of PubMed and Springerlink libraries were searched for retrospective case-control studies on delirium-related factors after THA. The retrieved studies were screened according to the inclusion criteria. Newcastle-Ottawa scale (NOS) was used to assess the quality of literatures. After extracting the data of included literatures, RevMan 5.3.5 software was used to analyze the data and obtain a forest plot and funnel plot. RESULTS: A total of 137 literatures were initially screened in this study. According to the inclusion and exclusion criteria and literature quality evaluation, 6 studies were finally included, involving a total of 3,494 patients. The NOS scores were above 6 points in all 6 literatures. Meta-analysis revealed statistical heterogeneity among the 6 studies (I2=80%, P=0.0002). The random effects model was used, revealing that the operation time of patients with postoperative delirium was longer, and the difference was statistically significant [standardized mean difference (SMD) =0.43, 95% confidence interval (CI): 0.20 to 0.66, P=0.0003]. The 6 studies were divided into unilateral or bilateral THA subgroups according to the type of surgery. Homogeneity was detected between the internal literatures: bilateral subgroup (I2=5%, P=0.37), unilateral subgroup (I2=0%, P=0.78). Postoperative delirium was associated with longer operation time in both subgroups, which was consistent with the combined analysis: bilateral subgroup (SMD =0.25, 95% CI: 0.12 to 0.37, P=0.0001), unilateral subgroup (SMD =0.70, 95% CI: 0.55 to 0.84, P=0.0001). DISCUSSION: Operation time is one of the related factors of delirium after THA. The longer the operation time, the greater the possibility of delirium.

Leaching characteristic of potentially toxic metals of artificial soil made from municipal sludge compost.

Landscaping of municipal sludge is a good choice to solve the sludge disposal problem, and EDTA treatment can effectively promote the uptake of heavy metals (HMs) by plants, but the heavy metal leaching process and its main control factors are still poorly understood during the sludge landscaping disposal. In this study, the migration behavior of HMs in artificial soil made from municipal sludge compost (MSC) were investigated using soil column experiments. After six leaching events for a total of one year's rainfall, the average reduction percentage of total phosphorus, total nitrogen, organic matter in the MSC artificial soil were 13.4%, 10.1%, and 7.8%, respectively, while those of copper, lead, zinc, cadmium, nickel were 12.9%, 8.37%, 11.5%, 5.94%, and 10.7%, respectively. Treating ethylenediaminetetraacetic acid (EDTA) to the MSC artificial soil further enhanced the leach index of HMs to different degrees. HM concentration in leachate were increased with peak times postponed. Though EDTA treatment increased HM concentrations in subsoil, it did not change their water washing efficiency. The retention of HMs in subsoil was related to properties of local soil and its interaction with leachate. The potential ecological risk was of quite strong risk category in the MSC artificial soil and rapidly decreased from moderate to slight risk in subsoil. Cadmium was the main contribution accounting for 46%-93% of ecological risk. For landscaping applications, the composition of MSC artificial soil and local soil, as well as the capacity of the surrounding water, needs to be considered.

Two-step adsorption model for Pb ion accumulation at the algae-water interface in the presence of fulvic acid.

The effects of fulvic acid (FA) on heavy metal bioaccumulation by algae have been extensively studied, but the quantitative description on its adsorption behavior is not elaborately illustrated. In the study, the two-step adsorption model is firstly proposed to describe the adsorption of Pb by algae in the presence of FA (R2 > 0.984), which is characterized with two-plateaus in the biosorption curves. The first plateau in the curve represents a monolayer adsorption process of free Pb2+; while the second reveals a multilayer adsorption process of Pb-FA binding to those adsorbed Pb by algae, and the bonding material was called as ternary complex of algae-Pb-(FA-Pb). The formation of the ternary complex caused a sharp increase of the amount of adsorbed Pb by algae which was measured by an atomic absorption spectrophotometry, and a decrease of the toxicity of Pb to algae verified with SEM and TEM images. The ternary phase diagram showed FA could participate in the formation of ternary complexes at very low concentration. The study is important for a comprehensive understanding of the metal-microalgae interaction and its biogeochemical cycle in surface waters.

The nature of dissolved organic matter determines the biosorption capacity of Cu by algae.

The role of dissolved organic matter (DOM) on the biochemical behavior and toxicity of heavy metals in water is very important but complex and unclear. The present work extracted DOM from a natural water and separated it into three fractions, namely humic acid (HA), fulvic acid (FA) and transphilic acid (TPA). Optical detection showed that HA had most aromatic ring skeletons, FA had more aromatic ring hydrophilic groups, and TPA had the largest number of hydroxyl or carboxyl groups. Their effects on the toxicity of Cu by Chlorella pyrenoidosa depended on types and concentration of DOM. In the case of algal exposure to 0.003 mM initial Cu concentration, the final algal optical density increased from 0.317 of the control group to 0.345, 0.645 and 0.435 in the presence of 20, 10 mg L-1 HA, and 10 mg L-1 TPA, respectively, but were suppressed to 0.246, 0.117 and 0.234 in the presence of 10, 20 mg L-1 FA and 20 mg L-1 TPA. Most adsorption isotherms lost the linearity in the presence of HA, FA and TPA. The adsorbed Cu increased from 0.242 to 0.477 mmol g-1, following the order of increased concentration of HA, FA, and TPA. The formation of ternary complex and the multi-layer adsorption were proposed to explain the significant enhancement adsorption of Cu in the presence of FA and TPA. This study showed that the type and the density of effective functional groups in DOM determined its effects on Cu toxicity and bioavailability to algae.

Bioaccessibility and health risk assessment of Pb and Cd in urban dust in Hangzhou, China.

Heavy metals in urban dust can enter the human body through a variety of ways, thus endangering human health. Understanding the bioaccessibility of heavy metals in urban dust is a key to its risk assessment. After the G20 summit in 2016, Hangzhou city has received much attention, including its environmental health risk. The surface dust collected from three different functional areas in Hangzhou were subjected to the in vitro physiologically based extraction test (PBET) to measure the bioaccessibility of Pb and Cd. In terms of spatial variation, the distribution of Pb bioaccessibility was in the order of residential areas > city parks > main roads > the Botanic Garden, while for Cd ordered in city parks > residential areas > main roads > the Botanic Garden. For temporal variation, the bioaccessibility of Pb was higher in autumn and winter, and the bioaccessibility of Cd was higher in spring and autumn. Based on multiple linear statistical analysis, the relationship between the spatial and temporal distribution differences of the bioaccessibility of Pb and Cd in the city and the main components was discussed. Meanwhile, the non-carcinogenic hazard quotients of Pb and the carcinogenic risk of Cd were calculated and showed no harm to human health, except the total Pb in the surface dust with a high non-carcinogenic risk for infants. Urban dust in Hangzhou city has a slight pollution and health risk from Pb. Currently, controlling and reducing the city's Pb emission is the key to maintain Hangzhou city's air quality and matching with its international tourism city.

Delineating the origin of Pb and Cd in the urban dust through elemental and stable isotopic ratio: A study from Hangzhou City, China.

Urban dust (UD) is one of the main sinks of heavy metals in urban environments; however, the sources of these heavy metals are quite difficult to identify. A total of 78 UD samples were collected bi-monthly from October 2012 to August 2013, including 13 sites from three functional areas (residential areas, city parks, and main roads) and the Botanic Garden as a control district. The metal ratios and lead isotopic ratios combined with correlation analysis were used to identify the sources of Pb and Cd in the UD samples. In the scatter plot of Cd/Mn vs Pb/Mn, the dust samples could be classified into four groups showing their different sources and characteristics. Lead isotopic composition analysis indicated that coal combustion was the main source of Pb for residential dusts, while automobile exhaust emission for road dusts. Correlation analysis revealed that the abraded paints was a main contribution of Cd in UD, especially those in city parks. The research provides a useful method of combining multiple approaches to identify sources of metal elements in UD.

Alteration of bioaccumulation mechanisms of Cu by microalgae in the presence of natural fulvic acids.

The impact of natural fulvic acids (FAs) on the toxicity and bioaccumulation of Cu by Chlorella pyrenoidosa was studied. FAs extracted from Taihu Lake were separated into three fractions using dialysis bags: F1 (<500 Da), F2 (500-1000 Da) and F3 (>1000 Da). The results showed that the F3 fraction with a larger molecular weight contained less acidic groups and unsaturated aliphatic structures than F1 and F2, and it showed stronger alleviation of the toxicity of Cu to algae. In the presence of F1∼F3, the bioaccumulation curve of Cu in algae intersected with the straight line in the binary system of Cu-algae at approximately 5.3 × 10-3－6.0 × 10-3 mM of Cu equilibrium concentration, showing an inhibition of bioaccumulation of Cu in lower concentrations but an enhancement in higher Cu concentrations. The ratio of {Cu}ads/{Cu}int was used to clarify the transformation mechanism on adsorption; the transition interval occurred at a ratio of 3.5-4.4. This ratio indicated a shift from a mechanism of slow trending to equilibrium to a mechanism with rapid increase, which may be due to the bridging action of Cu to form a ternary complex of FA-Cu-algae and the occurrence of multilayer adsorption. The promotion order of F1> F3> F2 was consistent with percentages of the carboxyl group in total acidic functional groups in the FAs. This research is helpful for improving the accuracy of present models for the prediction of heavy metal risks in aqueous environments.